Role of Resveratrol and Chrysin on Inflammation and Liver Function in Obese Mice

Abstract

The incidence of obesity has been spreading throughout the world. Many of the complications caused by obesity, such as inflammation and impaired liver function. Objectives: The purpose of this study was to investigate the effects of resveratrol and chrysin supplementation on inflammation and liver function of high-fat-diet induced obese mice. Methods: The C57BL/6 mice were randomly assigned to four groups: normal diet control (NC; n=10), high fat diet control (HC; n=10), and high fat diet with chrysin supplementation (HCH; n=10) groups. Resveratrol 25 mg/kg body weight and chrysin supplement 50mg/kg body weight were orally given dissolved in a 0.1ml solution of Dimethyl Sulfoxide (DMSO) per mouse 4 times a week for 15 weeks. Results: The calorie intake of the group supplemented by resveratrol and chrysin significantly decreased. The body weight significantly increased in the high-fat diet group compared with that in the normal diet group but not in the resveratrol and chrysin group after 15 weeks. The liver weight significantly decreased in the resveratrol group but in the chrysin group. TNFα did not significantly decrease in the resveratrol and chrysin group while IL1β significantly decreased. TLR 4 significantly decreased only in the chrysin group, while IL10 only increased in the resveratrol group. The collagen significantly decreased with resveratrol supplementation while fibronectin was not affected by resveratrol nor chrysin. Conclusions: The inflammation process in liver of high fat diet induced obese mice can be decreased by supplementation of resveratrol and chrysin. The liver function can change mostly by resveratrol supplementation.